Polycomb and Trithorax group proteins regulate silent Home Accent and active gene expression states, but also allow poised states in pluripotent cells.Here the authors present a mathematical model that integrates data on Polycomb/ Trithorax biochemistry into a single coherent framework which predicts that poised chromatin is not bivalent as previou
RAS mutations are among the most common oncogenic mutations in human cancers.Among RAS mutations, KRAS has the highest frequency and is present in almost 30% of non-small-cell lung cancer (NSCLC) patients.Lung cancer is the number one cause of mortality among cancers as a consequence of outrageous aggressiveness and late diagnosis.High mortality ra
Abstract Aiming at the engineering problem that 5G base station antenna is difficult to locate efficiently in complex electromagnetic environment, a two-stage positioning method of 5G base station antenna substation is proposed, which considers signal path loss and antenna RF radiation.Firstly, the path loss solution model of the 5G base station an
Each measurement system and a control principle must be based on certain facts about the system behaviour (what), operation (how) and structure (why).Each system is distributed into subsystems that provide an input for the next subsystem.For each system, start is important the begin, that means system ultra hold tape characteristics, collecting of